Why the study?
Does TGF-beta1 deficiency prevent Angiotensin II-induced cardiac hypertrophy in mice?
Population
TGF-beta1-deficient mice and wild-type mice
Comparison
Chronic subpressor doses of Angiotensin II vs Wild-type mice treated with the same dose of…
Design
Preclinical
Authors
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Hypothesis-generating for TGF-β1 blockade in Ang II hypertrophy; clinical trials needed before human translation.
Does TGF-beta1 deficiency prevent Angiotensin II-induced cardiac hypertrophy in mice?
TGF-beta1 is an important mediator of the hypertrophic growth response of the heart to Angiotensin II.
Schultz et al. (2002) studied this question.
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