Answers are grounded in this paper and cite their sources.
Eplet mismatches in HLA-DQ confer substantial risk for de novo DSA formation, graft rejection, and graft failure after kidney transplantation. Mismatches in other loci seem to have less effect. The results suggest that antibody-verified HLA-DQ eplet mismatch load could be used to guide personalized post-transplant immunosuppression. Adoption of molecular matching for DQA₁ and DQB₁ alleles could also help to minimize de novo DSA formation and potentially improve transplant outcomes.
No takes yet. Share an insight, caveat, or question.
Senev et al. (2020) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: