The Role of Adipokines in Health and Disease

Figures

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  Figure 1. The behavior of adipokines in relation to the adipose tissue status of an individual. In healthy adipose tissue, anti-inflammatory adipokines increase while proinflammatory adipokines decrease, whereas the opposite is true in obese adipose tissue, increasing the likelihood of cardiovascular and metabolic diseases.

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  Figure 2. Metabolic illness is described by the altered behavior of adipokines. A rise in proinflammatory adipokines and a fall in anti-inflammatory adipokines can have an effect on appetite and other factors. Liver steatosis and cardiovascular atherogenesis are both possible. In addition, insulin production from the pancreas is disrupted and insulin sensitivity is compromised.

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  Figure 3. The pathogenesis of obesity induces a low-grade inflammation that generates a dysregulation in the adipose tissue and microbiota, which affects our immune system and results in an increase in intestinal permeability.