Why the study?
Does oral propranolol alter sympathetic and parasympathetic indicators of heart rate control during altitude acclimatization in male subjects?
Population
9 male subjects undergoing acclimatization at altitude (Pike's Peak, CO, 4,300 m)
Comparison
Oral propranolol 240 mg/day vs Matched placebo
Design
RCT, Randomly assigned, Matched placebo
Follow-up
11-12 days
Authors
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Propranolol modulates autonomic tone at altitude; confirms dual SNS/PNS involvement in hypoxic tachycardia and supports targeted use in acclimatization.
Does oral propranolol alter sympathetic and parasympathetic indicators of heart rate control during altitude acclimatization in male subjects?
Both parasympathetic and sympathetic nervous systems are involved in elevated heart rate during early altitude acclimatization, which is modulated by propranolol.
Hughson et al. (1994) studied this question.