Does tissue Doppler-derived mitral E/Ea ratio reliably predict intracardiac filling pressures in decompensated patients with advanced systolic heart failure?
Tissue Doppler-derived mitral E/Ea ratio has limited reliability for estimating filling pressures in advanced decompensated systolic heart failure, especially in the presence of severe LV dilation, low cardiac index, or CRT.
In decompensated patients with advanced systolic heart failure, tissue Doppler-derived mitral E/Ea ratio may not be as reliable in predicting intracardiac filling pressures, particularly in those with larger LV volumes, more impaired cardiac indices, and the presence of cardiac resynchronization therapy.
Müllens et al. (2008) studied this question.