Why the study?
Does tissue Doppler-derived mitral E/Ea ratio reliably predict intracardiac filling pressures in decompensated patients with advanced systolic heart failure?
Does tissue Doppler-derived mitral E/Ea ratio reliably predict intracardiac filling pressures in decompensated patients with advanced systolic heart failure?
Tissue Doppler-derived mitral E/Ea ratio has limited reliability for estimating filling pressures in advanced decompensated systolic heart failure, especially in the presence of severe LV dilation, low cardiac index, or CRT.
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Caution against relying on E/Ea for filling pressures in advanced systolic HF; leaves open validation of alternative noninvasive markers.
In decompensated patients with advanced systolic heart failure, tissue Doppler-derived mitral E/Ea ratio may not be as reliable in predicting intracardiac filling pressures, particularly in those with larger LV volumes, more impaired cardiac indices, and the presence of cardiac resynchronization therapy.
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Müllens et al. (2008) studied this question.
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