Effects of Calorie Restriction and Voluntary Exercise on Doxorubicin-Induced Cardiotoxicity

Figure 1.. Experimental design.

Figure 2.. Cardiac function data for saline groups. No significant differences were observed between saline-treated groups for left ventricular developed pressure (A), end systolic pressure (B), maximal rate of pressure development (C), minimal rate of pressure development (D), or fractional shortening (E). Dashed line represents Control group data.

Figure 3.. Fractional shortening. DOX significantly decreased FS, while the combination of CR and WR increased fractional shortening significantly. Dashed line represents Control group data. Data are mean ± SEM. *P < .05 versus CON. #P < .05 versus DOX.

Figure 4.. Cardiac function in the isolated perfused working heart. CR + DOX and CR + WR + DOX had significantly increased LVDP (A) and ESP (B) compared with DOX. The maximal rate of left ventricle pressure development (C) was significantly greater in CR + DOX and CR + WR + DOX compared with DOX, while the minimum rate of left ventricle pressure development (D) was significantly decreased in CR + WR + DOX compared with DOX. Dashed line represents CON group data. Data are mean ± SEM. *P < .05 versus CON. #P < .05 versus DOX.

Figure 5.. Cardiac doxorubicin accumulation. Animals in the CR + WR + DOX group had significantly less DOX accumulation in the left ventricle compared with animals the DOX group. Data are mean ± SEM. #P < .05 versus DOX.