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Photoacoustic technology in combination with molecular imaging is a highly effective method for accurately diagnosing brain glioma. For glioma detection at a deeper site, contrast agents with higher photoacoustic imaging sensitivity are needed. Herein, we report a MoS₂-ICG hybrid with indocyanine green (ICG) conjugated to the surface of MoS₂ nanosheets. The hybrid significantly enhanced photoacoustic imaging sensitivity compared to MoS₂ nanosheets. This conjugation results in remarkably high optical absorbance across a broad near-infrared spectrum, redshifting of the ICG absorption peak and photothermal/photoacoustic conversion efficiency enhancement of ICG. A tumor mass of 3.5 mm beneath the mouse scalp was clearly visualized by using MoS₂-ICG as a contrast agent for the in vivo photoacoustic imaging of orthotopic glioma, which is nearly twofold deeper than the tumors imaged in our previous report using MoS₂ nanosheet. Thus, combined with its good stability and high biocompatibility, the MoS₂-ICG hybrid developed in this study has a great potential for high-efficiency tumor molecular imaging in translational medicine.
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Liu et al. (2018) studied this question.