August 29, 2014The Journal of PhysiologyOpen Access

Spinal μ‐opioid receptor‐sensitive lower limb muscle afferents determine corticospinal responsiveness and promote central fatigue in upper limb muscle

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Why the study?

Does lumbar intrathecal fentanyl blockade of lower limb muscle afferents prevent supraspinal fatigue and alter corticospinal responsiveness in upper limb muscles during leg cycling?

Population

8 males

Comparison

Lumbar intrathecal fentanyl during constant-load… vs Control conditions

Design

Other

Authors

SSSimranjit K. SidhuThe University of Adelaide JWJoshua C. WeavilLipocine (United States)MVMassimo VenturelliHeart Failure & Transplant

Discussion

Member takes

Implication

Afferent blockade may blunt remote supraspinal fatigue; leaves open translation to clinical populations or performance.

Structured PICO

Does lumbar intrathecal fentanyl blockade of lower limb muscle afferents prevent supraspinal fatigue and alter corticospinal responsiveness in upper limb muscles during leg cycling?

Population

8 males

Intervention

Lumbar intrathecal fentanyl during constant-load leg cycling exercise (80% peak power output) for 30 s (non-fatiguing) and to exhaustion (~9 min; fatiguing)

Comparator

Control conditions (constant-load leg cycling exercise without fentanyl)

Outcome

Voluntary activation (VA) of elbow flexors assessed via transcranial magnetic stimulation (TMS) during maximum voluntary contraction (MVC) and corticospinal responsiveness monitored via TMS-evoked potentials (MEPs)surrogate

Group III/IV locomotor muscle afferents facilitate supraspinal fatigue in remote muscles and inhibit corticospinal responsiveness during fatiguing exercise.

Cite This Study

Sidhu et al. (2014) studied this question.

synapsesocial.com/papers/69d779ccf44a16d01ef314d8 https://doi.org/10.1113/jphysiol.2014.275438

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Spinal μ‐opioid receptor‐sensitive lower limb muscle afferents determine corticospinal responsiveness and promote central fatigue in upper limb muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Spinal μ‐opioid receptor‐sensitive lower limb muscle afferents determine corticospinal responsiveness and promote central fatigue in upper limb muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider