Key result
Tranexamic acid inhibits PE resolution, while perfusion scans consistently underestimate residual emboli.
Why the study?
Resolution of emboli in dogs can be inhibited by tranexamic acid, and the extent of embolic residuals is underestimated by perfusion lung scans.
Does tranexamic acid inhibit the resolution of emboli in dogs with chronic pulmonary thromboembolism?
Does tranexamic acid inhibit the resolution of emboli in dogs with chronic pulmonary thromboembolism?
In a canine model of chronic pulmonary thromboembolism, tranexamic acid inhibits emboli resolution, and perfusion lung scans underestimate residual emboli.
Tranexamic acid may impair embolus resolution in this canine model; leaves open translation to human pulmonary embolism care and scan accuracy.
Resolution of emboli in the canine can be inhibited by tranexamic acid. As in humans, a spectrum of embolic residuals is encountered, and the perfusion lung scan consistently underestimates the extent of embolic residuals. Studies of this animal model continue.
No takes yet. Share an insight, caveat, or question.
Moser et al. (1991) studied this question. Tranexamic acid inhibits the resolution of pulmonary emboli in dogs, and perfusion lung scans consistently underestimate the extent of the resulting embolic residuals.
Synapse has enriched 5 related papers. Consider them for comparative context: