Large Language Model–Driven Knowledge Graph Construction in Sepsis Care Using Multicenter Clinical Databases: Development and Usability Study

This study represents a pioneering effort in using LLMs, particularly GPT-4.0, to construct a comprehensive sepsis knowledge graph. The innovative application of prompt engineering, combined with the integration of multicenter real-world data, has significantly enhanced the efficiency and accuracy of knowledge graph construction. The resulting knowledge graph provides a robust framework for understanding sepsis, supporting clinical decision-making, and facilitating further research. The success of this approach underscores the potential of LLMs in medical research and sets a new benchmark for future studies in sepsis and other complex medical conditions.