Outcomes among pediatric patients with cancer who are treated on trial versus off trial: A matched cohort study

This is the authors' abstract. We don't add key points for this paper.

There was no statistically significant difference in outcomes noted between those patients treated on trial and those treated with standard therapy and/or off trial. However, in partial support of the clinical trial effect, the results of the current study indicate a trend toward more favorable outcomes in children treated on trial compared with those treated with standard therapy and/or off trial. These findings can support decision making regarding enrollment in pediatric phase 3 clinical trials.