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Preclinical investigation reveals that Alox15 and 15-HpETE promote cardiomyocyte ferroptosis during ischemia-reperfusion injury, indicating a target to limit cardiac damage.
Together, our results established that Alox15/15-HpETE-mediated cardiomyocyte ferroptosis plays an important role in prolonged I/R injury.
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Cai et al. (2023) studied this question.
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