Animal study demonstrates that soluble amyloid oligomers trigger enduring tau phosphorylation in tauopathy mice, indicating brief amyloid elevations cause lasting neurodegeneration.
Soluble Aβ(1-42) oligomers have long-lasting effects on tau phosphorylation in the rTg4510 model, possibly due to elevations in GSK3. These data suggest that even brief elevations in Aβ production, may have enduring impact on the risk for tauopathy.
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Selenica et al. (2012) studied this question.
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