Patients with atrial fibrillation and pathogenic TTN variants have a more severe clinical course, including a high risk (~50%) of developing LV systolic dysfunction or malignant ventricular arrhythmias, necessitating specialized diagnostic evaluation and management.
TTN(+) AF patients undergo more cardioversions and have more persistent forms of AF. Approximately 50% develop LV systolic dysfunction and/or malignant ventricular arrhythmias. These results highlight the need for diagnostic evaluation and management in TTN(+) patients beyond the usual care for AF.
Virk et al. (Wed,) studied this question.