Formation–dissociation of glucose, pH and redox triply responsive micelles and controlled release of insulin

An amphiphilic copolymer containing PEO and PAPBA linked by a disulfide bond (PEO–SS–PAPBA) was synthesized by RAFT. The micelles with a PEO shell and a PAPBA core presented glucose, pH and redox triple responses. The controlled release of insulin could be achieved through adding glucose or GSH.