December 1, 1984European Heart Journal

The relationship between action potential duration and force of contraction in rat myocardium

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Population

Ventricular trabeculae of adult rats at 26 degrees C

Comparison

Various experimental interventions including… vs Baseline or control conditions prior to…

Design

Preclinical

Authors

VSVincent J. A. SchoutenMedtronic (Netherlands)

Discussion

Member takes

Implication

Hypothesis-generating for Ca2+-dependent APD-force coupling in rat myocardium; extends basic models but leaves human translation open.

Structured PICO

Population

Ventricular trabeculae of adult rats at 26 degrees C

Intervention

Various experimental interventions including paired-pulse stimulation, addition of Sr2+, nifedipine, substitution of extracellular NaCl by LiCl, and increase of [Ca2+]o

Comparator

Baseline or control conditions prior to interventions

Outcome

Intracellular action potentials (APD50 and APD10) and peak force (F) of isometric contractionssurrogate

The study proposes a model explaining the relationship between action potential duration and force of contraction in rat myocardium based on intracellular Ca2+ transport, slow inward current, and Na+/Ca2+ exchange.

Cite This Study

Vincent J. A. Schouten (1984) studied this question.

synapsesocial.com/papers/69d7bf1bf39344339dd17e47 https://doi.org/10.1093/oxfordjournals.eurheartj.a061618

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