The water-soluble gold(III) complex [Au(III)(butyl-C^N)biguanide]Cl (butyl-HC^N = 2-(4-n-butylphenyl)pyridine, BCN) displays cytotoxicity through S-phase cell cycle arrest and endoplasmic reticulum (ER) damage in HeLa cells, and shows a promising anti-angiogenic effect at sub-cytotoxic concentrations.
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Zhang et al. (2012) studied this question.