June 7, 2023Open Access

Higher versus lower blood pressure targets after cardiac arrest: Systematic review with individual patient data meta-analysis

VNVille NiemeläUniversity of Helsinki FSFaiza SiddiquiCopenhagen University Hospital KAKoen AmelootInterventional Cardiology

Structured PICO

Does targeting a higher MAP reduce mortality or improve neurologic recovery in patients after cardiac arrest?

Population

Patients after cardiac arrest (CA)

Intervention

Targeting a higher mean arterial pressure (MAP)

Comparator

Targeting a lower mean arterial pressure (MAP)

Outcome

Mortality or neurologic recoveryhard clinical

In an individual patient data meta-analysis, targeting a higher MAP after cardiac arrest did not significantly reduce mortality or improve neurologic recovery compared to a lower MAP target.

Abstract

Targeting a higher MAP compared to a lower MAP is unlikely to reduce mortality or improve neurologic recovery after CA. Only a large treatment effect above 25% (RR < 0.75) could be excluded, and future studies are needed to investigate if relevant but lower treatment effect exists. Targeting a higher MAP was not associated with any increase in adverse effects.

KI fragen

Bookmark

View Full Paper