December 20, 2022Cardiovascular ResearchOpen Access

Cholesterol accumulation in macrophages drives NETosis in atherosclerotic plaques via IL-1β secretion

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MYMustafa YalçınkayaColumbia University Irving Medical Center PFPanagiotis FotakisColumbia University Irving Medical Center WLWenli LiuLudong University

Abstract

These studies establish a new link between inflammasome-mediated IL-1β production in macrophages and NETosis in atherosclerotic plaques. Macrophage-derived IL-1β appears to increase NETosis both by increasing neutrophil recruitment to plaques and by promoting neutrophil NLRP3 inflammasome activation.

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Yalçınkaya et al. (2022) studied this question.

synapsesocial.com/papers/69d7c42005ee2ba81dbedc86 https://doi.org/10.1093/cvr/cvac189

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Cholesterol accumulation in macrophages drives NETosis in atherosclerotic plaques via IL-1β secretion

Abstract

Discussion

Cite This Study

Cholesterol accumulation in macrophages drives NETosis in atherosclerotic plaques via IL-1β secretion

Abstract

Discussion

Cite This Study

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