Mechanistic model demonstrates enhanced cholesterol efflux in inflamed macrophages, suggesting a protective acute phase response mediated by serum amyloid A and sPLA2-IIa.
Current data support a model for the acute phase response in which serum amyloid A and sPLA2-IIa, present at sites of inflammation and tissue damage, play a protective role by enhancing cellular cholesterol efflux, thereby promoting the removal of excess cholesterol from macrophages.
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Westhuyzen et al. (2007) studied this question.
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