Selection criteria for early breast cancer patients in the DBCG proton trial – The randomised phase III trial strategy

Key Points

Define the dosimetric patient selection criteria for enrollment in the randomized phase III DBCG Proton Trial for early-stage breast cancer.
Established radiation dose-volume threshold criteria to identify early breast cancer patients eligible for inclusion in the randomized trial.
Patient selection requires a mean heart radiation dose of ≥ 4 Gy.
Patient selection alternately requires a lung radiation volume parameter of V17Gy or V20Gy ≥ 37%.

Study defines dosimetric selection criteria in early breast cancer patients, suggesting targeted allocation to proton therapy.

The patient selection criteria for the DBCG Proton Trial are mean heart dose ≥ 4 Gy and/or lung V17Gy/V20Gy ≥ 37%.

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Stick et al. (2021) studied this question.

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