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There is no need to prescribe steroids (dexamethasone) beyond day 1 after AC HEC, whereas a 4-day regimen is recommended in non-AC HEC. Olanzapine is now recommended as a fixed part of a four-drug prophylactic antiemetic regimen in both non-AC and AC HEC. No major differences between 5-HT₃ receptor antagonists or between NK₁ receptor antagonists were identified. No new antiemetic agents qualified for inclusion in the updated recommendations.
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Herrstedt et al. (2023) studied this question.
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