Spontaneous remission lasting more than a decade in untreated AQP4 antibody-positive NMOSD

This is the authors' abstract. We don't add key points for this paper.

Neuromyelitis optica spectrum disorder (NMOSD) associated with aquaporin-4 antibody (AQP4-Ab) predominantly targets the optic nerve and spinal cord and is characterized by frequent relapses and accrual of irreversible disability.1 Variations in clinical course may include an initial or predominant involvement in extra spinal/optic nerve locations and a benign course marked by mild attacks and minimal residual deficits.2,3 However, spontaneous remissions are rare. We are reporting 2 patients who satisfied the 2015 criteria for NMOSD4 and had a unique disease course highlighted by periods of spontaneous remission lasting 19 and 23 years.