Increased frequency of proinflammatory CD4 T cells and pathological levels of serum neurofilament light chain in adult drug‐resistant epilepsy

Oumarou Ouédraogo; Rose‐Marie Rébillard; Hélène Jamann; Victoria Mamane; Marie‐Laure Clénet; Audrey Daigneault; Boaz Lahav; Timo Uphaus; Falk Steffen; Stefan Bittner; Frauke Zipp; Arline Bérubé; Samuel Lapalme‐Remis; Patrick Cossette; Dang Khoa Nguyen; Nathalie Arbour; Mark R. Keezer; Catherine Larochelle

doi:10.1111/epi.16742

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Abstract

Our data support that DRE is associated with an expansion of the CD4 Tcell subset in the peripheral blood and with a shift toward a proinflammatory Th17/Th1 CD4 Tcell immune profile. Our results further show that pathological levels of sNfL are more frequent in DRE, supporting a potential neurodegenerative component in adult DRE. With this work, we provide evidence for novel potential inflammatory and degenerative biomarkers in DRE.

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Ouédraogo et al. (2020) studied this question.

synapsesocial.com/papers/69d7c9b6ec32c73b01ae298d https://doi.org/10.1111/epi.16742

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Increased frequency of proinflammatory CD4 T cells and pathological levels of serum neurofilament light chain in adult drug‐resistant epilepsy

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Abstract

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Increased frequency of proinflammatory CD4 T cells and pathological levels of serum neurofilament light chain in adult drug‐resistant epilepsy

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