Why the study?
Evidence regarding whether and how periostin actively contributes to inflammation-associated tumorigenesis remained elusive.
Does periostin deficiency prevent colorectal tumorigenesis in mouse models of colitis-associated colorectal cancer?
Population
Azoxymethane/dextran sulfate sodium-treated mice and ApcMin/+ mice
Comparison
Periostin deficiency vs non-deficient control
Design
Preclinical animal study
Authors
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Periostin inhibition merits exploration as a target in colitis-associated colorectal cancer; human translation remains untested.
Does periostin deficiency prevent colorectal tumorigenesis in mouse models of colitis-associated colorectal cancer?
Periostin promotes colorectal tumorigenesis via tumor-stroma interactions, identifying it and IL-6 as potential therapeutic targets for colitis-associated colorectal cancer.
Ma et al. (2020) studied this question.
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