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August 16, 2000Journal of Clinical Oncology3,829 citations

Leucovorin and Fluorouracil With or Without Oxaliplatin as First-Line Treatment in Advanced Colorectal Cancer

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AGAimery de GramontAFArié FigerMSMichel Seymour

Key Points

  • This research aims to evaluate the effectiveness of the LV5FU2-oxaliplatin regimen as a first-line treatment for advanced colorectal cancer.
  • Utilized LV5FU2-oxaliplatin as the treatment regimen.
  • Assessed progression-free survival.
  • Evaluated quality of life during treatment.
  • The LV5FU2-oxaliplatin combination improved progression-free survival compared to standard treatment.
  • The regimen was well-tolerated with acceptable side effects.
  • Quality of life was maintained during the treatment period.

Abstract

The LV5FU2-oxaliplatin combination seems beneficial as first-line therapy in advanced colorectal cancer, demonstrating a prolonged progression-free survival with acceptable tolerability and maintenance of QoL.

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Cite This Study

Gramont et al. (2000) studied this question.

synapsesocial.com/papers/69d7cd4e319e71454dbedabbhttps://doi.org/10.1200/jco.2000.18.16.2938
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Statistical Tables for the Design of Clinical Trials.1988 · 433 citations
  2. 2Oxaliplatin added to the simplified bimonthly leucovorin and 5-fluorouracil regimen as second-line therapy for metastatic colorectal cancer (FOLFOX6)1999 · 290 citations
  3. 3The European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-of-Life Instrument for Use in International Clinical Trials in Oncology1993 · 16,182 citations
  4. 4Nonparametric Estimation from Incomplete Observations1958 · 39,402 citations
  5. 5Superiority of sequential methotrexate, fluorouracil, and leucovorin to fluorouracil alone in advanced symptomatic colorectal carcinoma: a randomized trial.1989 · 113 citations