High Frequency of Activating <emph type="ital">PIK3CA</emph> Mutations in Human Papillomavirus–Positive Oropharyngeal Cancer<alt-title><emph type="ital">PIK3CA</emph> in HPV+ Oropharyngeal Squamous Cell Carcinoma</alt-title>

Although there has been a suggestion that activating PIK3CA mutations are common in HPV-positive HNSCC, to our knowledge, this is the first study to clearly identify this phenomenon. Targeting PIK3CA with molecular agents in HPV-positive patients may be a mechanism to improve cure rates and decrease treatment toxic effects in this rapidly growing cohort of patients.