Answers are grounded in this paper and cite their sources.
The exposure-response relationship of eplontersen was well characterised by the PKPD model. Weight and injection site were found to affect systemic exposure, but this effect does not seem to result in clinically relevant variation in response.
No takes yet. Share an insight, caveat, or question.
Diep et al. (2022) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: