Why the study?
Does APOE ε4 carrier status modify the relationship between postoperative day 2 CRP levels and postoperative delirium?
Does APOE ε4 carrier status modify the relationship between postoperative day 2 CRP levels and postoperative delirium?
APOE ε4 carrier status may act as a genetic modifier in the association between early postoperative inflammation and the development of delirium.
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May refine postoperative delirium risk models with genetic data; leaves open prospective validation before clinical use.
Our findings raise the possibility that APOE ε4 carrier status may modify the relationship between postoperative day 2 CRP levels and postoperative delirium.
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Vasunilashorn et al. (2019) studied this question.
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