August 7, 2018Frontiers in PhysiologyOpen Access

The Newly Synthesized Pyrazole Derivative 5-(1-(3 Fluorophenyl)-1H-Pyrazol-4-yl)-2H-Tetrazole Reduces Blood Pressure of Spontaneously Hypertensive Rats via NO/cGMO Pathway

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Why the study?

Does the newly synthesized pyrazole derivative LQFM-21 reduce blood pressure in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHR) and isolated aortic rings from SHR

Design

Preclinical

Follow-up

15 days

Authors

NTNeidiane Rosa TrindadeUniversidade Federal de Goiás PLPaulo Ricardo LopesUniversidade Federal de Goiás LNLara Marques NavesUniversidade Federal de Goiás

Discussion

Member takes

Implication

Provides preclinical support for LQFM-21 in hypertension; leaves open translation to human efficacy and safety.

Structured PICO

Does the newly synthesized pyrazole derivative LQFM-21 reduce blood pressure in spontaneously hypertensive rats?

Population

Spontaneously hypertensive rats (SHR) and isolated aortic rings from SHR

Intervention

5-(1-(3 fluorophenyl)-1H-pyrazol-4-yl)-2H-tetrazole (LQFM-21) via acute intravenous administration (0.05, 0.1, 0.2, and 0.4 mg kg-1) or chronic oral administration (15 mg kg-1 for 15 days)

Outcome

Mean arterial pressure (MAP) and heart rate (HR)surrogate

The newly synthesized pyrazole derivative LQFM-21 lowers blood pressure and induces vasodilation in hypertensive rats via the NO/cGMP pathway.

Cite This Study

Trindade et al. (2018) studied this question.

synapsesocial.com/papers/69d7ec02ba18484428d1822d https://doi.org/10.3389/fphys.2018.01073

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The Newly Synthesized Pyrazole Derivative 5-(1-(3 Fluorophenyl)-1H-Pyrazol-4-yl)-2H-Tetrazole Reduces Blood Pressure of Spontaneously Hypertensive Rats via NO/cGMO Pathway

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Newly Synthesized Pyrazole Derivative 5-(1-(3 Fluorophenyl)-1H-Pyrazol-4-yl)-2H-Tetrazole Reduces Blood Pressure of Spontaneously Hypertensive Rats via NO/cGMO Pathway

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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