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Observational study reveals mucosal bacterial dysbiosis in paediatric inflammatory bowel disease, highlighting the pathogenic role of mucosa-adherent microbes.
This is the first paediatric report investigating the intestinal mucosa-associated microflora in patients of the IBD spectrum. These results, although limited by the sample size, allow a better understanding of changes in mucosa-associated bacterial flora in these patients, showing either a predominance of some potentially harmful bacterial groups or a decrease in beneficial bacterial species. These data underline the central role of mucosa-adherent bacteria in IBD.
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Conte et al. (2006) studied this question.
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