August 30, 2013Hepatology269 citationsOpen Access

Transforming Growth Factor Beta Signaling in Hepatocytes Participates in Steatohepatitis Through Regulation of Cell Death and Lipid Metabolism in Mice

LYLing YangUniversity of Oxford YRYoon Seok RohChungbuk National University JSJingyi SongArmy Medical University

Structured PICO

Population

Mice

Intervention

TGF-β signaling in hepatocytes

Outcome

Hepatocyte death and lipid accumulationsurrogate

TGF-β signaling in hepatocytes promotes the development of NASH via Smad signaling and ROS production.

Abstract

TGF-β signaling in hepatocytes contributes to hepatocyte death and lipid accumulation through Smad signaling and ROS production that promote the development of NASH.

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Cite This Study

Yang et al. (Fri,) studied this question.

synapsesocial.com/papers/69d7f18b66a29169b4bed886 https://doi.org/https://doi.org/10.1002/hep.26698

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