Why the study?
Does withholding Angiotensin Receptor Blockers in the early postoperative period increase 30-day mortality in postoperative patients?
Does withholding Angiotensin Receptor Blockers in the early postoperative period increase 30-day mortality in postoperative patients?
Withholding Angiotensin Receptor Blockers in the early postoperative period is associated with increased 30-day mortality, suggesting prompt resumption may be beneficial.
Cautious interpretation needed given observational design; leaves open whether prompt ARB resumption improves survival.
Postoperative delay in resuming ARB is common, particularly in patients who are frail after surgery. Withholding ARB is strongly associated with increased 30-day mortality, especially in younger patients, although residual confounding may be present.
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Lee et al. (2015) studied this question.
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