Why the study?
Does preoperative angiotensin axis blockade therapy increase the risk of postinduction hypotension and acute kidney injury in patients undergoing major elective orthopedic surgery?
Does preoperative angiotensin axis blockade therapy increase the risk of postinduction hypotension and acute kidney injury in patients undergoing major elective orthopedic surgery?
Preoperative angiotensin axis blockade in major orthopedic surgery is associated with increased risks of hypotension, acute kidney injury, and prolonged hospital stay.
May warrant AAB caution in orthopedic surgery; leaves open whether discontinuation improves outcomes in RCTs.
Patients undergoing major elective orthopedic surgery who receive preoperative AAB therapy,have an associated increased risk of postinduction hypotension and postoperative acute kidney injury resulting in a greater hospital length of stay.
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Nielson et al. (2014) studied this question.
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