Why the study?
Does continuation or de novo initiation of ACE inhibitors improve in-hospital outcomes in patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass?
Population
Patients undergoing coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass
Comparison
Continuation of ACE inhibitor or de novo ACEI… vs Withdrawal of ACEI treatment after coronary…
Design
Cohort
Follow-up
in-hospital
Authors
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May warrant caution with ACEI withdrawal post-CABG; hypothesis-generating and requires RCTs before practice change.
Does continuation or de novo initiation of ACE inhibitors improve in-hospital outcomes in patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass?
Continuing or initiating ACE inhibitors early after CABG surgery may improve in-hospital outcomes and prevent ischemic events compared to withdrawing therapy.
Drenger et al. (2012) studied this question.
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