September 1, 2003Anesthesia & Analgesia
Calcium Channel Blockers for Reducing Cardiac Morbidity After Noncardiac Surgery: A Meta-Analysis
Why the study?
Do calcium channel blockers reduce cardiac morbidity (death, MI, ischemia, SVT, CHF) in patients undergoing noncardiac surgery?
Population
1007 patients undergoing noncardiac surgery (pooled from 11 RCTs)
Comparison
Calcium channel blockers administered in the… vs Control
Design
Meta-analysis
Authors
Discussion
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Overview
Supports perioperative CCB use, especially diltiazem, to reduce ischemia and SVT in noncardiac surgery; reinforces Level 1 evidence for cardiac protection.
Structured PICO
Do calcium channel blockers reduce cardiac morbidity (death, MI, ischemia, SVT, CHF) in patients undergoing noncardiac surgery?
P
Population
1007 patients undergoing noncardiac surgery (pooled from 11 RCTs)
I
Intervention
Calcium channel blockers (CCBs) administered in the perioperative setting
C
Comparator
Control (specifics not explicitly defined in the abstract)
O
Outcome
Death, myocardial infarction (MI), ischemia, supraventricular tachyarrhythmia (SVT), and congestive heart failure (CHF)hard clinical
Perioperative administration of calcium channel blockers, particularly diltiazem, significantly reduces ischemia and supraventricular tachyarrhythmia during noncardiac surgery.
Cite This Study
Wijeysundera et al. (2003) studied this question.