Curcumin may protect against doxorubicin-induced cardiotoxicity by modulating autophagy and pyroptosis via the PI3K/Akt/mTOR pathway.
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Hypothesis-generating for curcumin in doxorubicin cardiotoxicity; leaves open translation to human cardioprotection.
Our finding suggested that Cur rescued against DOX-induced cardiac injury probably through regulation of autophagy and pyroptosis in a mTOR-dependent manner.
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Yu et al. (2020) studied this question.
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