What question did this study set out to answer?

Evaluate the relationship between specific antibiotic exposures, treatment durations, and the risk of acquiring carbapenem-resistant extended-spectrum-β-lactamase-producing Klebsiella pneumoniae (ESBL-CRKP) infections in hospitalized patients.

March 31, 2011Journal of Antimicrobial Chemotherapy

Antibiotic use and the risk of carbapenem-resistant extended-spectrum- -lactamase-producing Klebsiella pneumoniae infection in hospitalized patients: results of a double case-control study

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Authors

EKEvangelos I. KritsotakisUniversity of Crete CTConstantinos TsioutisEuropean University Cyprus MRMaria RoumbelakiHellenic Mediterranean University

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Implication

Double case-control study demonstrates increased risk of drug-resistant Klebsiella pneumoniae from combination antibiotic therapies in hospitalized patients, highlighting the need for cautious...

Key Points

Evaluate the relationship between specific antibiotic exposures, treatment durations, and the risk of acquiring carbapenem-resistant extended-spectrum-β-lactamase-producing Klebsiella pneumoniae (ESBL-CRKP) infections in hospitalized patients.
Conducted a double case-control study among hospitalized patients.
Evaluated exposure and duration of therapy across multiple antibiotic classes, focusing on β-lactam/β-lactamase inhibitor combinations and carbapenem-fluoroquinolone regimens.
Treatment and longer duration of treatment with β-lactam/β-lactamase inhibitor combinations were associated with an increased risk of ESBL-CRKP infection.
Combination therapy utilizing carbapenems alongside fluoroquinolones significantly contributed to the risk of ESBL-CRKP infection.

Cite This Study

Kritsotakis et al. (2011) studied this question.

synapsesocial.com/papers/69d80cd761e2ce1627d18a10 https://doi.org/10.1093/jac/dkr116

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Implication

Double case-control study demonstrates increased risk of drug-resistant Klebsiella pneumoniae from combination antibiotic therapies in hospitalized patients, highlighting the need for cautious...

Antibiotic use and the risk of carbapenem-resistant extended-spectrum- -lactamase-producing Klebsiella pneumoniae infection in hospitalized patients: results of a double case-control study

Discussion

Member takes

Implication

Key Points

Cite This Study

Antibiotic use and the risk of carbapenem-resistant extended-spectrum- -lactamase-producing Klebsiella pneumoniae infection in hospitalized patients: results of a double case-control study

Discussion

Member takes

Implication

Key Points

Cite This Study

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