Depressive symptoms are increased in the early perimenopausal stage in ethnically diverse human immunodeficiency virus–infected and human immunodeficiency virus–uninfected women

In HIV-infected and HIV-uninfected women, the odds of elevated depressive symptoms were significantly higher during early perimenopause. Elevated depressive symptoms were associated with nonadherence to HAART, underscoring the importance of screening and treating depressive symptoms in HIV-infected women who have experienced a change in the regularity of their menstrual cycles.