What question did this study set out to answer?

To evaluate the clinical efficacy of remdesivir and three repurposed antiviral regimens on in-hospital mortality and disease progression in hospitalised COVID-19 patients.

May 1, 2022The LancetOpen Access

Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses

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To evaluate the clinical efficacy of remdesivir and three repurposed antiviral regimens on in-hospital mortality and disease progression in hospitalised COVID-19 patients.
Multicenter, international, randomized clinical trial conducted across global hospital sites under the WHO Solidarity protocol.
Hospitalised patients with COVID-19 were randomly assigned to receive standard of care alone or standard of care supplemented with remdesivir, hydroxychloroquine, lopinavir, or interferon beta-1a.
Remdesivir and the comparator repurposed drugs did not produce a statistically significant reduction in overall in-hospital mortality compared to standard care alone.
Treatment arms showed no significant decrease in the initiation of mechanical ventilation or total duration of hospital stay among admitted patients.

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Implication

Randomized trial demonstrates no significant mortality reduction with remdesivir in hospitalised COVID-19 patients, indicating limited utility of repurposed antivirals.

Abstract

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Cite This Study

Pan et al. (2022) studied this question.

synapsesocial.com/papers/69d80e0ca2a48916bbbeebd2 https://doi.org/10.1016/s0140-6736(22)00519-0

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Implication

Randomized trial demonstrates no significant mortality reduction with remdesivir in hospitalised COVID-19 patients, indicating limited utility of repurposed antivirals.

Abstract

Who.

Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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