Does selective inhibition of PDE4B protect cardiac function in patients with acute myocardial infarction designated for reperfusion therapy?
Selective inhibition of PDE4B is proposed as a potential therapeutic target to reduce neutrophil inflammation and microvascular obstruction in acute myocardial infarction.
PDE4B is critically involved in neutrophil inflammation and microvascular obstruction, leading to MI/R injury. Selective inhibition of PDE4B might protect cardiac function in patients with acute myocardial infarction designated for reperfusion therapy.
Wan et al. (Thu,) studied this question.