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July 27, 2022SHILAP Revista de lepidopterologíaOpen Access

Cross-reactivity of eight SARS-CoV-2 variants rationally predicts immunogenicity clustering in sarbecoviruses

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Why the study?

A steep rise in Omicron reinfection cases suggested increased immune evasion ability, prompting evaluation of its antigenicity relationship with other variants.

Does a Beta or Omicron booster elicit broad neutralizing antibodies against SARS-CoV-2 variants including Omicron BA.1?

Population

Guinea pigs immunized with spike protein of SARS-CoV-2 VOCs and VOIs

Comparison

Antisera cross-tested against pseudotyped variants, including Beta or Omicron 4th-dose booster

Design

Preclinical immunization and in silico structural analysis study

Follow-up

3-months after the 3rd dose

Authors

QLQianqian LiLZLi ZhangZLZiteng Liang

Discussion

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Overview

Beta or Omicron boosters may broaden neutralization preclinically; leaves open human translation and optimal variant vaccine design.

Structured PICO

Does a Beta or Omicron booster elicit broad neutralizing antibodies against SARS-CoV-2 variants including Omicron BA.1?

P
Population
Guinea pigs immunized with spike protein of SARS-CoV-2 variants of concern (VOCs) and variants of interest (VOIs), along with in silico analysis of 280 antigen-antibody structures and 715 neutralizing antibodies
I
Intervention
Immunization with spike proteins of SARS-CoV-2 variants, including a 4th dose booster of Beta or Omicron 3 months after the 3rd dose
C
Comparator
Other variants used as immunogens
O
Outcome
Neutralization activity against pseudotyped variantssurrogate

A 4th dose booster with Beta or Omicron variants elicits broad neutralizing antibodies against all current SARS-CoV-2 variants, providing key information for rational vaccine design.

Cite This Study

Li et al. (2022) studied this question.

synapsesocial.com/papers/69d8100aba18484428d185e9https://doi.org/10.1038/s41392-022-01123-7
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ten emerging SARS-CoV-2 spike variants exhibit variable infectivity, animal tropism, and antibody neutralization2021 · 61 citations
  2. 2Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron2022 · 479 citations
  3. 3Assessment of Neutralizing Antibody Response Against SARS-CoV-2 Variants After 2 to 3 Doses of the BNT162b2 mRNA COVID-19 Vaccine2022 · 44 citations
  4. 4Characterization of the significant decline in humoral immune response six months post‐SARS‐CoV‐2 mRNA vaccination: A systematic review2022 · 137 citations