Why the study?
Does normalization of HDL-C promote the loss of monocyte-derived cells from atherosclerotic plaques in a mouse model?
Population
Plaque-bearing aortic arches from apolipoprotein E-deficient (apoE-/-) mice (low HDL-C, high non-HDL-C)
Comparison
Transplantation into recipient mice with normal… vs Transplantation into recipient mice with low…
Design
Preclinical
Follow-up
1 week
Authors
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HDL normalization may drive rapid plaque regression in this mouse model; leaves open translation to human therapies.
Does normalization of HDL-C promote the loss of monocyte-derived cells from atherosclerotic plaques in a mouse model?
In a mouse model, HDL promotes rapid atherosclerosis regression by regulating the migratory and inflammatory properties of monocyte-derived cells in plaques.
Feig et al. (2011) studied this question.
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