External radiation exposure, excretion, and effective half-life in 177Lu-PSMA-targeted therapies

In terms of the radiation exposure to the public, ¹⁷⁷Lu-PSMA is a safe option of radionuclide therapy. As usually four (sometimes more) cycles of the therapy are performed, it must be conducted in a way that ensures that applicable legal requirements can be followed. In other words, the radiation exposure to the public and the concentration of activity in wastewater must be sub-marginal. Therefore, in certain countries, hospitalization of these patients is mandatory.