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Lower ACE mRNA and protein levels are associated with increased schizophrenia risk, suggesting a need for pharmacovigilance regarding ACE inhibitor use in susceptible patients.
Findings suggest an adverse association of lower ACE messenger RNA and protein levels with schizophrenia risk. These findings warrant greater pharmacovigilance and further investigation into the effect of ACE inhibitors, particularly those that are centrally acting, on psychiatric symptoms in patients with schizophrenia, as well as the role of ACE inhibitor use in late-onset schizophrenia.
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Chauquet et al. (2021) studied this question.
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