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June 3, 2009SHILAP Revista de lepidopterologíaOpen Access

CpG methylation profiling in VHL related and VHL unrelated renal cell carcinoma

Fiona E. McRonald Mark R. Morris Dean Gentle Laura Winchester Dilair Baban Jiannis Ragoussis Noel W. Clarke Michael D. Brown Takeshi Kishida Masahiro Yao Farida Latif Eamonn R. Maher

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Abstract

These findings demonstrate differing patterns of tumour-specific CpG methylation in VHL and non VHL clear cell RCC and papillary RCC, and identify multiple novel potential CpG methylation biomarkers for RCC.

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McRonald et al. (2009) studied this question.

synapsesocial.com/papers/69d81c733eff0c9dfaae36f7 https://doi.org/10.1186/1476-4598-8-31

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Identification of the von Hippel-Lindau Disease Tumor Suppressor GeneOriginal Research · 1993 · 2,976 citations
2Genetic and Epigenetic Analysis of von Hippel-Lindau ( <i>VHL</i> ) Gene Alterations and Relationship with Clinical Variables in Sporadic Renal CancerOriginal Research · 2006 · 275 citations
3Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.Original Research · 1994 · 1,529 citations
4Inactivation of the von Hippel–Lindau ( <i>VHL</i> ) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for a <i>VHL</i> ‐independent pathway in clear cell renal tumourigenesisOriginal Research · 1998 · 270 citations
5Tumor Suppressor Activity and Epigenetic Inactivation of Hepatocyte Growth Factor Activator Inhibitor Type 2/SPINT2 in Papillary and Clear Cell Renal Cell CarcinomaOriginal Research · 2005 · 124 citations

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