Why the study?
Systemic RV dysfunction in ccTGA can be aggravated by chronic pacing-induced dyssynchrony, contributing to progression of heart failure.
Is transvenous cardiac resynchronization therapy feasible and effective for improving functional status in a pacing-dependent patient with dextrocardia, complex ccTGA, and a failing systemic right ventricle?
Is transvenous cardiac resynchronization therapy feasible and effective for improving functional status in a pacing-dependent patient with dextrocardia, complex ccTGA, and a failing systemic right ventricle?
Transvenous CRT is anatomically feasible and clinically beneficial for managing pacing-induced systemic right ventricular dysfunction in patients with complex congenitally corrected transposition of the great arteries.
Supports transvenous CRT consideration in select complex ccTGA cases; leaves open need for prospective validation before broader use.
Systemic RV dysfunction in ccTGA can be aggravated by chronic pacing-induced dyssynchrony, contributing to progression of heart failure in this patient group. Transvenous CRT is feasible in ccTGA anatomy and may be pursued in order to improve or preserve the functional status of pacing-dependent ccTGA patients. Invasive haemodynamic contractility evaluation can help assess the potential benefit of CRT in patients with complex anatomy.
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Nederend et al. (2021) studied this question.