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September 7, 1999Circulation575 citationsOpen Access

Purple Grape Juice Improves Endothelial Function and Reduces the Susceptibility of LDL Cholesterol to Oxidation in Patients With Coronary Artery Disease

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JSJames H. SteinJKJon G. KeevilDWDonald A. Wiebe

Structured PICO

Does short-term ingestion of purple grape juice improve endothelial function and reduce LDL oxidation in patients with coronary artery disease?

P
Population
Patients with coronary artery disease (CAD)
I
Intervention
Short-term ingestion of purple grape juice
O
Outcome
Endothelial function (flow-mediated dilation [FMD]) and susceptibility of LDL cholesterol to oxidationsurrogate

Short-term ingestion of purple grape juice improves endothelial function and reduces LDL oxidation in patients with coronary artery disease, suggesting a potential mechanism for cardiovascular benefit from flavonoids.

Abstract

Short-term ingestion of purple grape juice improves FMD and reduces LDL susceptibility to oxidation in CAD patients. Improved endothelium-dependent vasodilation and prevention of LDL oxidation are potential mechanisms by which flavonoids in purple grape products may prevent cardiovascular events, independent of alcohol content.

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Cite This Study

Stein et al. (1999) studied this question.

synapsesocial.com/papers/69d81ff43eff0c9dfaae3788https://doi.org/10.1161/01.cir.100.10.1050
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