Canonical Wnt signals combined with suppressed TGFβ/BMP pathways promote renewal of the native human colonic epithelium

Amy G. Reynolds; Natalia Wharton; Alyson Parris; Esther M. Mitchell; Anastasia Sobolewski; Christy Kam; Loren Bigwood; Ahmed El Hadi; Andrea Münsterberg; Michael Lewis; C. Speakman; William Stebbings; Richard Wharton; Kevin Sargen; Richard Tighe; Crawford P. Jamieson; James Hernon; Sandeep Kapur; Naohide Oue; Wataru Yasui; Mark R. Williams

doi:10.1136/gutjnl-2012-304067

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Abstract

Steady-state tissue renewal in the native human colonic epithelium is dependent on canonical Wnt signals combined with suppressed TGFβ/BMP pathways. Stem/progenitor cell proliferation is uncoupled from crypt cell migration and shedding, and is required to constantly replenish the crypt cell population.

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Reynolds et al. (2013) studied this question.

synapsesocial.com/papers/69d820f961e2ce1627d18d7e https://doi.org/10.1136/gutjnl-2012-304067

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Canonical Wnt signals combined with suppressed TGFβ/BMP pathways promote renewal of the native human colonic epithelium

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Abstract

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Canonical Wnt signals combined with suppressed TGFβ/BMP pathways promote renewal of the native human colonic epithelium

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Abstract

Discussion

Cite This Study

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