Association of sleep disturbance and itch intensity with quality-of-life impairment and disease severity in prurigo nodularis

In this study, we explored the relationship between itch intensity, sleep disturbance and quality-of-life (QoL) impairment in patients with prurigo nodularis (PN). Using validated assessment tools, we found significant correlations between self-reported itch severity, objective disease measures, and their impact on sleep and QoL. These findings highlight the profound burden of PN on patients’ daily lives and the importance of addressing both itch and sleep disturbances in managing this condition.